DescriptionArtificial Intelligence (AI) is currently generating much interest and research including applications to healthcare. However, this is not the first time AI has generated a lot of hype and raised hopes for what can be accomplished through the application of AI. For decades AI has been lauded as a solution to problems and research funding and interest has followed just to be met with disappointing results and the reduction in funding. Then a new wave of interest spurs on renewed interest and hype. These cycles have come to be known as AI Winters. There is a plethora of opportunities to apply AI to healthcare, yet if done without consideration for the human, this foray can fail and affect trust in the technology. Indeed, the EHR system Epic has recently come under scrutiny for its Sepsis AI algorithm delivering inaccurate results. The field of Human Factors can and should be involved with the development of AI to aid in understanding how human performance may be affected, including overreliance on AI, underuse and mistrust, maintaining situation awareness, and trust repair. This panel will highlight potential applications of AI in healthcare while also discussing how Human Factors can augment the design and application of AI.